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Cadexomer iodine
Cadexomer iodine is an iodophor that is produced by the reaction of dextrin with epichlorhydrin coupled with ion-exchange groups and iodine. It is a water-soluble modified starch polymer containing 0.9% iodine, calculated on a weight-weight basis, within a helical matrix.〔Merck Index, 14th Edition, p262 Merck & Co. Inc.〕
==History==
Cadexomer iodine was developed in the early 1980s in Sweden by Perstorp AB, and given the name Iodosorb. The product was shown to be effective in the treatment of venous ulcers,.〔Skog, E. et al. (1983). A randomized trial comparing cadexomer iodine and standard treatment in the out-patient management of chronic venous ulcers. ''British Journal of Dermatology'' 109, 77. PMID 6344906〕〔Ormiston, M.C., Seymour, M.T., Venn, G.E., Cohen, R.I. and Fox, J.A. (1985). Controlled trial of Iodosorb in chronic venous ulcers. ''British Medical Journal (Clinical Research Edition)'' 291, 308-310. PMID 3962169〕
More recently, it has been shown in studies in animals and humans that, unlike the iodophor povidone-iodine, Iodosorb causes an acceleration of the healing process in chronic human wounds. This is due to an increase in epidermal regeneration and epithelialization in both partial-thickness and full-thickness wounds.〔Drosou Anna, Falabella Anna, and Kirsner Robert S. (2003) Antiseptics on Wounds: An area of controversy. ''Wounds'' 159(5) 149-166. http://cme.medscape.com/viewarticle/456300_2 Retrieved 02/03/2009〕 In this way cadexomer iodine acts as a cicatrizant.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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